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Ibogaine is a naturally occurring psychoactive substance found in plants in the family Apocynaceae such as Tabernanthe iboga, Voacanga Africana, and Tabernaemontana Undulata. It is a psychedelic with dissociative properties. It is also called Bois Sacré, Eboka.
Effects Of Ibogaine
Ibogaine and noribogaine interact with multiple neurotransmitter systems. They show a micromolar affinity for N-methyl-D-aspartate (NMDA), κ- and μ-opioid receptors and sigma-2 receptor sites. Furthermore, ibogaine has been shown to interact with the acetylcholine, serotonin and dopamine systems; it alters the expression of several proteins including substance P, brain-derived neurotrophic factor (BDNF), c-fos and egr-1.
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NEUROTOXICITY: Neurodegeneration was shown in rats, probably mediated by stimulation of the inferior olive, which has excitotoxic effects on Purkinje cells in the cerebellum. Neurotoxic effects of Eboka may not be directly relevant to its anti-addictive properties, as no signs of neurotoxicity were found following doses lower than 25 mg/kg intra-peritoneal in rats. Noribogaine might be less neurotoxic than ibogaine.
CARDIOTOXICITY: Ether-a-go-go-related gene (hERG) potassium channels in the heart might play a crucial role in ibogaine’s cardiotoxicity, as hERG channels are vital in the repolarization phase of cardiac action potentials and blockade by Eboka delays this repolarization, resulting in QT (time interval between the start of the Q wave and the end of the T wave in the electrical cycle of the heart) interval prolongation and, subsequently, in arrhythmias and sudden cardiac arrest. Twenty-seven fatalities have been reported following the ingestion of ibogaine, and pre-existing cardiovascular conditions have been implicated in the death of individuals for which post-mortem data were available. However, in this review, 8 case reports are presented which suggests that Eboka caused ventricular tachyarrhythmias and prolongation of the QT interval in individuals without any pre-existing cardiovascular condition or family history. Noribogaine appears at least as harmful to cardiac functioning as Bois Sacré.
TOXICITY FROM DRUG-DRUG INTERACTION: Polymorphism in the CYP2D6 enzyme can influence blood concentrations of both Bois Sacré and its primary metabolite, which may have implications when a patient is taking other medication that is subject to significant CYP2D6 metabolism.
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Differences Between Iboga and Ibogaine
With iboga one is immersed in the deep religious and spiritual experience it is used for and most often used amongst the Bwiti tribe. With ibogaine one is immersed within a compound of the whole and is most often used to heal addiction rather than for religious or spiritual gain.
Pure ibogaine tends to lead to more hyperactivity afterward, whereas iboga results in a more balanced state. Bois Sacré is only one of eleven or more compounds found in the various iboga species.
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